【摘要】 目的:了解北京、新疆库尔勒不同地区、性别、民族、生活环境成年人消化性溃疡（PU）的检出率及与幽门螺旋杆菌（H.Pylori,HP）感染的关系,进一步了解内地和大西北地区PU与HP感染的流行特点。方法:2000年7-12月对北京、库尔勒（塔里木石油工人）两地有上腹不适症状的患者1802例,年龄在14～86岁,进行常规电子胃镜检查和快速尿素酶（HPRUT）实验;取胃窦、胃体黏膜做病理（Giemsa染色）找HP,我院除上述方法外,还采用¹³C呼气实验,判断HP的感染。结果:（1）北京汉族、库尔勒汉族和维族患者十二指肠球溃疡（Du）检出率分别为9.2%、18.1%和23.1%（P<0.01）; 胃溃疡（Gu）检出率分别为2.2%、5.0%和7.7%（P<0.01）。（2）北京汉族、库尔勒汉族和维族男性患者DU检出率分别为10.3%、25.6%和25.0%（P<0.01）;GU检出率分别为0.6%、8.1%和8.3%（P<0.01）;女性的DU检出率分别为7.7%、8.7%、和19.7%（P<0.01）;GU检出率分别为4.3%、1.1%、和6.6%（P<0.01）。（3）北京汉族、库尔勒汉族和维族DU患者合并HP感染的检出率分别为72%、84.4%和92.3%（P>0.05）;GU患者合并HP感染的检出率分别为50.0%、63.6%和75.0%（P>0.05）。结论:库尔勒地区的PU患者检出率高于我院的PU患者检出率;两地相同性别间的PU检出率不同,库尔勒地区男性PU患者的检出率明显高于北京PU患者;库尔勒地区女性PU患者的检出率明显高于北京PU患者;两地间PU患者中合并HP感染的检出率相同,无明显差异。研究表明:地区不同、性别、民族不同和社会环境不同其PU的发病率不同,其病因是多层次、多因素、多水平的。更多还原

【Abstract】 Objective: To study the interrelation between the detection rate of the peptic ulcer (the duodenal ulcer and the gastric ulcer) and the H. Pylori infection in Beijing and Korla,to further find out the detection rate of the peptic ulcer and the clinical feature of the H. Pylori infection occurred in the hinterland and Northwest in China.Methods: From July to December 2000, l802 cases, who are rural/urban citizens in Beijing and Korla (including the workers from the Talimu Oilfield) from 14 to 86 years old, were given the electronic gastroescopy test and the HPRUT and the pathological section from the mucosa on the gastric sinus and the gastric body to look for H. Pylori (Giemsa Staining), 13C - UBT was made to make out the H. Pylori infection in Beijing. Results: (1) Suffered by the Hans in our hospital, the Hans and the Uygurs in Korla, the detection rates of the duodenal ulcer (DU) were 9.2% , 18.1% and 23.1% (P < 0.01); and the detection rates of the gastric ulcer (GU) were 10.3% , 25.6% and 25.0% (P < 0.01). (2) Suffered by the male of the Hans in our hospital, and the Hans and the Uygurs in Korla, the detection rates of DU were 10.3%, 25.6% and 25.0% (P < 0.01) and those of GU were 0.6% , 8.1% and 8.9% (P < 0.01) respectively. Suffered by the female the detection rate of DU was 7.7%, 8.7%, 19.7% (P < 0.01) and that of GU were 4. 3% , 1.1%, 6.6% (P<0.0l). (3) Suffered by the Hans in our hospital, the Hans and the Uygurs in Korla, the detection rates of DU with H. Pylori infection were 72% , 84.4% and 92.3% (P > 0.05). The detection rate of GU with H.Pylori infection was 50.0% , 63.6% and 75.0% (P > 0.05). Conclusion: The detection rate of the PU in Korla was higher than that in Beijing. There was no significant difference on the detection rate of the PU with H. Pylori infection in the two places. The above study showed the detection rate of the PU differed due to different places, sexes, nationalities and social environment. The causes of the disease are various.更多还原