【摘要】 目的探讨弹力纤维、Ⅳ型胶原、CD44v6表达与肺腺癌转移的相关性。方法应用弹力纤维染色、免疫组织化学方法观察56例肺腺癌,了解弹力纤维、Ⅳ型胶原、CD44v6的表达状况,分析其与肺腺癌转移的关系。结果弹力纤维、Ⅳ型胶原、CD44v6表达在有、无淋巴结转移组中皆有显著差异(P=0.000);并与淋巴结有否转移显著相关(r=-0.581、0.476、0.635;P<0.01)。结论弹力纤维、Ⅳ型胶原、CD44v6表达与肺腺癌转移密切相关,对其检测有助于对肺腺癌转移及预后做出判断。更多还原

【Abstract】 Objective To study the expression of elastic fibers,Collagen type Ⅳ and CD44v6 in the metastasis of the pulmonary adenocarcinoma.Methods In paraffin-embedded specimens from 56 cases of pulmonary adenocarcinoma,the elastic fibers were stained with histochemical method and the expressions of collagen type Ⅳ and CD44v6 were detected with immunohistochemical method.Results The positive expression rates of elastic fibers,collagen type Ⅳ and CD44v6 were 11.5%(3/26),11.5%(3/26) and 80.8%(21/26)in the group with lymph node metastasis,and were 69.0%(20/29),55.2%(16/29) and 24.1%(7/29) in the group without lymph node metastasis,respectively.The expression of elastic fibers,collagen type Ⅳ and CD44v6 were significant difference in the two groups with and without lymph node metastasis(P=0.000).There was statistically significant correlation among elastic fibers,collagen type Ⅳ,CD44v6 and lymph node metastasis(all P<0.01).Conclusion There is significant correlation among elastic fibers,collagen type Ⅳ,CD44v6 and lymph node metastasis.Detection of elastic fibers,collagen type Ⅳ and CD44v6 may be used as predictors of the metastasis and prognosis of pulmonary adenocarcinoma.更多还原