【摘要】 L-组氨酸(L-His)在醛的催化下,在羧酸溶剂中能发生消旋.当反应温度升高时,消旋反应速率加快.L-His用(R)-酒石酸((R)-TA)做拆分试剂,在乙酸溶剂中、水杨醛存在下进行不对称转换,合成了D-组氨酸(D-His)的酒石酸盐,经处理得到D-His.在最佳工艺条件下的收率为95.76%,光学纯度大于99.5%.更多还原

【Abstract】 L-Histidine (L-His) could be racemized in carboxylic acids which were used as solvents in presence of catalyst such as butanal .The rate of racemization of L-His increased with the increase of the temperature. The water in carboxylic acid decreased the rate of racemization. An asymmetric transformation from L-His to D-His through formation of salt with (R)-tartaric acid was achieved by using salicylaldehyde as a catalyst for epimerization in acetic acid, and D-His (R)-TA salt was obtained, treatment of the salt gave D-His with optical purity 100% in 95.76% yield based on the starting material under the optimistic conditions.更多还原