【摘要】 研究了聚醚-壳聚糖水凝胶的制备方法,聚醚与壳聚糖质量比、凝胶温度、交联剂戊二醛浓度等对聚醚-壳聚糖水凝胶的溶胀度、硬度的影响。采用正交实验对工艺条件进行了优化,正交实验的结果表明:当聚醚与壳聚糖质量比为0.4、凝胶温度为45℃、交联剂浓度为0.05mol/L 时,其凝胶饱和溶胀度为837%;当聚醚与壳聚糖质量比为0.6、凝胶温度为45℃、交联剂浓度为0.15mol/L 时,其凝胶硬度为436g。聚醚-壳聚糖水凝胶具有良好的生物相容性。更多还原

【Abstract】 Polyether-chitosan hydrogel is synthesized and the effects of the mass ratio of polyether and chi- tosan,temperature,the concentration of crosslinker on swelling ratio and hardness are studied and optimized by using orthogonal experimetnal method.The results show that the swelling ration of hydrogel is 837% at a polyether to chi- tosan ration of 0.4,a temperature of 45℃,a concentration of crosslinker of 0.05 mol/L and the hardness of hydrogel is 436g when gelled at 45℃ with a polyether to chitosan ration of 0.6,and a concentration of crosslinker of 1.5mol/ L.Polyether-chitosan hydrogel has good biocompatibility.更多还原