【摘要】 将手性二胺(1S,2S)-1,2-二苯基乙二胺二磺酸钠((1S,2S)-DPENDS)修饰的钌膦配合物用于催化水/有机两相体系中苯乙酮的不对称加氢.结果表明,(1S,2S)-DPENDS和KOH的浓度对反应有很大影响,二者的协同作用使配合物的催化活性和产物的对映选择性大大提高.对温度、压力、底物/钌的摩尔比和膦配体/钌摩尔比等反应条件进行优化后,以[RuCl2-(TPPTS)2]2为催化剂前体催化苯乙酮不对称加氢时,产物的ee值可达66.4%,催化剂经过简单的相分离即可循环使用.更多还原

【Abstract】 The catalytic performance of ruthenium phosphine complex [RuCl₂（TPPTS）₂]₂（TPPTS: trisodium salt of tri（m-sulfophenyl） phosphine） using（（1S,2S）-1,2-diphenyl-1,2-ethylene） diamine sulfonate disodium（（（1S,2S）DPENDS）） as chiral modifier for the asymmetric hydrogenation of acetophenone and its derivatives in an organic/aqueous biphase catalytic system was investigated.The concentration of（（S,S）-DPENDS） and/or KOH could strongly influence the catalytic performance of the ruthenium complex catalyst.The synergistic effect between（（1S,2S）-DPENDS） and KOH could significantly accelerate the reaction rate and enhance the enantioselectivity for（R）-phenylethanol.An ee value of 66.4% was obtained under the optimized conditions.The products could be conveniently separated from the reaction system by decantation,and both the ruthenium complex catalyst and（（1S,2S）-DPENDS） were left in the aqueous phase and could be used repeatedly.更多还原