【摘要】 目的探讨异基因造血干细胞移植后纯红细胞再生障碍性贫血(PRCA)的发生机制。方法报道1例病例并进行文献复习。结果1例诊断为骨髓增生异常综合征(MDS-RAEBT)组织配型相合、ABO血型不合的患者进行造血干细胞移植获得成功,但移植后出现PRCA,经红细胞生成素治疗失败,改用激素治疗后血红蛋白恢复正常。结论免疫因素及a抗体是ABO血型不合造血干细胞移植后致PRCA的最可能原因;糖皮质激素(泼尼松)是治疗ABO血型不合造血干细胞移植后PRCA的有效、经济、安全的药物。更多还原

【Abstract】 Objective To study pure red cell aplasia(PRCA) of complication after ABO- incompatible allogeneic stem cell transplantation. Methods A patient who was diagnosed as myelodysplastic syndrome (MDS- RAEBT) was developed PRCA after HLA- identical, but ABO- incompatible allogeneic stem cell transplantation. Results Erythroid engraftment was successful with steroid treatment after the failure of erythropoietin. We concluded that immune factor and anti- A isoagglutinin is the most important reason of PRCA after HLA- identical but ABO- incompatible allogeneic stem cell transplantation. Conclusions Steroid (Prednisone) is the effective, economical, safe drug to treat PRCA after ABO- incompatible allogeneic stem cell transplantation.更多还原