【摘要】 目的:探讨β-连环素(β- catenin)的表达与胆管癌的临床病理参数和预后的关系,寻找胆管癌早期诊断及判断预后的方法,指导临床对胆管癌的治疗。方法:采用S- P法对8例正常人胆总管、4例先天性胆总管囊肿和2 5例胆管癌标本中β- catenin的表达情况进行免疫组化分析研究。结果:β- catenin在胆管癌组中表达阳性率为10 0 % ,明显高于先天性胆总管囊肿(75 % )和正常胆总管(6 2 .5 % ) (Z=- 3.0 3,P<0 .0 1)。β- catenin在胆管癌的表达情况与胆管癌的病理分型(Hc=2 .13,P>0 .0 5 )、原发部位(Hc=5 .2 5 ,P>0 .0 5 )及黄疸指数(Hc=6 .0 6 ,P>0 .0 5 )无关,与分化程度(Hc=9.35 ,P<0 .0 1)、浸润深度(Hc=12 .6 2 ,P<0 .0 1)、神经浸润程度(Hc=9.2 8,P<0 .0 1)及临床分期(Hc=15 .4 9,P<0 .0 1)有关。结论:β- catenin在胆管癌中的表达情况与胆管癌的有关临床病理参数有关,可作为胆管癌预后的良好标志物。更多还原

【Abstract】 Objective To investigate the correlations between the expression of β-catenin and clinicopathologic parameters in bile duct carcinoma (BDC), and evaluate the potential prognostic value. Methods The expressions of β-catenin in 8 samples of normal bile ducts, 4 samples of congenital choledochal cyst and 25 samples of BDC were detected by immunohistochemistry staining (S-P method). Results The β-catenin positive expression rate in BDC samples (100%) was obviously higher than those in samples of congenital choledochalcyst(75%) and normal bile ducts(62.5%) (Z=-3.03,P<0.01). The expressions of β-catenin in BDC were correlated with histological grade(Hc=9.35,P<0.01), infiltration grade (Hc=12.62,P<0.01),perineural invasion (Hc=9.28,P<0.01), clinical stage(Hc=15.49,P<0.01), and were incorrelated with pathologic type(Hc=2.13,P>0.05), location(Hc=5.25,P>0.05), and severity of jaundice (Hc=6.06,P>0.05). Conclusion β-catenin is correlated with some clinicopathologic parameters of BDC and can be used as a valuable prognostic marker of BDC.更多还原