【摘要】 目的:探讨万拉法新的神经保护作用及其机制。方法:采用体外原代培养的大鼠海马神经元,复制谷氨酸损伤模型以模拟抑郁症时的病理改变,在体外通过MTT法检测万拉法新对神经元存活率的影响,并且测定万拉法新应用前后L DH的释放、GSH水平、MDA含量和SOD活性的改变情况。结果:万拉法新抵抗了谷氨酸诱导的神经元损伤,提高了神经元存活率,减少了L DH的释放,维持细胞膜的完整性,提高了神经细胞内SOD活性和GSH水平,降低了MDA含量。结论:万拉法新具有神经保护作用。更多还原

【Abstract】 Objective To investigate the neuroprotection of Venlafaxine and its mechanism. Methods The influence of Venlafaxine on the survival rates of primary cultured hippocampal neurons injured by glutamate to mimic the changes in depression was detected with MTT method;the LDH release, GSH activity, SOD activity, and MDA value were detected before and after treatment with Venlafaxine. Results Venlafaxine prevented the neurons in himppocampus from the damage induced with glutamate, elevated the neurons survival rates, reduced the LDH release, kept the cell membrane intact, elevated the SOD activity and GSH activity and decreased the MDA level. Conclusion Venlafaxine possesses the neuroprotection.更多还原