【摘要】 采用放免法检测58例甲亢和47例甲减患者血浆心钠素(ANF)和内皮素(ET)水平。甲亢未治组ANF和ET水平显著高于甲亢缓解组、甲减未治组、甲减治疗组及对照组(P<0.01), ANF和 ET水平与血清 FT3、FT4 存在正相关。甲亢缓解组、甲减未治组和治疗组ANF浓度与对照组比较无显著性差异(P>0 05),但甲减未治组ANF明显低于治疗组(P< 0 05)。甲亢缓解组、甲减治疗组 ET 与对照组比较无显著性差异(P>0 05),但甲减未治疗组ET均明显低于其它组(P<0 01,P<0 05)。测定 ANF和 ET对甲亢和甲减的辅助诊断和疗效观察具有一定临床价值。更多还原

【Abstract】 Plasma atrial natriuretic factor(ANF) and endothelin(ET) were detected by RIA in 58 cases of hyperthyroidism and 47 cases of hypothyroidism.Before the ANF and ET concentration of untreatment hyperthyroid patients was much higher than that of treatment hyperthyroid patients, hypothyroid patients before and after treatment and the normal group(P<0.01).The concentration of ANF and ET was remarkably correlative with FT 3 and FT 4. Compared with the normal group, ANF concentration in treatment hyperthyroid patients, hypothyroid patients before and after treatment was no significantly different(P>0.05),but that in hypothyroid patients before treatment was significantly decreased compared with hypothyroid patients after treatment( P<0.05).Compared with the normal group, ET concentration in hyperthyroid patients and hypothyroid patients after treatment was no significantly different( P>0.05), but that in hypothyroid patients before treatment was significantly decreased compared with others (P<0.01 and P<0.05).Detection of ANF and ET level may be have a role in supplementary diagnosis and curative effect observation of hyperthyroidism and hypothyroidism.更多还原