【摘要】 ①目的比较止血芳酸与抑肽酶在体外循环中对血小板的保护作用。②方法测定止血芳酸组与抑肽酶组的血小板计数、术后出血量、输血量及体外循环前后血浆α-颗粒膜蛋白(GMP-140)、血栓烷B2(TXB2)和6-酮-前列腺素F1α(6-K-PGF1α)的浓度变化。③结果两组间血小板计数、术后出血量及输血量、血浆GMP-140、TXB2和6-K-PGF1α比较差异无显著性(t=0.65~1.70,P>0.05)。④结论止血芳酸与抑肽酶在体外循环中对血小板的保护作用相似。更多还原

【Abstract】 Objective To compare the effects of acidium para-aminomethylben zoicum （APAMZ） and aprotinin on the protection of platelets during cardiopulmonary bypass （CPB）. Methods Platelet counts and amount of blood loss and transfusion were recorded after CPB, GMP-140, TXB₂ and 6-K- PGF_1αassessed before and after CPB in the APAMZ group and aprotinin group. Results No significant difference existed between the two groups in platelet counts, amount of blood loss and transfusion needed, and plasma GMP-140, TXB₂ and 6-K- PGF_1α（t=0.65-1.70,P>0.05）. Conclusion APAMZ and aprotinin have similar protecting effects on platelets during CPB.更多还原