【摘要】 ①目的　通过观察过量性激素对成年新西兰兔喉的影响,探讨性激素与喉部疾病发病机制的相关性,并为临床上应用性激素治疗喉部疾病提供组织学理论依据。②方法　将 40 只健康成年新西兰兔分为 3 组。雌激素组肌注苯甲酸雌二醇,雄激素组肌注丙酸睾丸酮,对照组不用药。分期处死,取喉固定。解剖显微镜下测量喉部支架数值,光镜下观察兔喉组织结构变化。③结果　过量雄激素可使成年兔喉支架增大,呈雄性化表现;过量雌激素使成年雌兔维持或强化雌性喉的特征,雄兔雌性化。雌激素组喉上皮厚度增加,杯状细胞增多,黏膜下水肿,淋巴细胞浸润;雄激素组喉内外肌增粗,肌纤维束致密。④结论　性激素对成年兔喉黏膜上皮作用明显。过量雄激素可致成年兔喉支架及喉肌纤维发生变化,而雌激素此作用不明显。性激素作为机体内环境的组成部分,对于喉癌的发生和发展可能产生一定影响。雌激素在喉的营养和免疫方面起重要作用。更多还原

【Abstract】 Objective To study the effect of excessive sex hormone on normal larynx of adult rabbits to reveal the correlation between sex hormone and the laryngeal diseases and to provide the histological basis in clinical treatment of the diseases by using sex hormone. Methods Forty healthy New Zealand adult rabbits were divided into three groups. The rabbits in androgen group were injected testosterone propionate; those in estrogen group were injected estradiol benzoate; while those in control group nothing was given. The experimental animals were killed at different stages, and the larynges removed and fixed. The laryngeal anatomic numerical value was measured under dissecting microscope and the histological structure change was observed under a light microscope. Results Excessive androgen enlarged the laryngeal cavity of the adult rabbits. Excessive estrogen kept or strengthened the characteristics of the female throat in the adult female rabbits, and the male rabbits were feminized. In the estrogen group, the laryngeal epithelium was thicken, the cup cell increased, the hydrops was under the mucous membrane, and the lymphocyte was soaked. The internal and external muscles of the throats of the androgen group increased, and the muscle fascicules were compact. Conclusion Sex hormones have obvious effects on laryngeal epithelium. The excessive androgen leads to the changes on adult laryngeal cavity and muscle fibers, whereas the estrogen was not obvious. As part of the internal environment, the sex hormones may influence the occurrence and development of the throat cancer. Estrogen plays an important role in laryngeal trophic and immunity conditions.更多还原