【摘要】 目的:观察荫风轮总苷的急性和慢性毒性反应。方法:荫风轮总在灌胃测定小鼠最大给药量,观察7d内动物的死亡情况;大鼠分为对照组,荫风轮总苷高、中、低剂量组(940,470,235mg·kg-1/d),连续灌胃4周及停药2周。结果:荫风轮总苷的小鼠的最大给药量为8.0g·kg-1/d,相当于临床成人试用量的476.19倍。荫风轮总苷高、中、低剂量组,均可明显缩短凝血时间,高、中剂量组升高总蛋白(TP)、白蛋白(ALB)作用与对照组差异有显著性,高剂量组可明显降低血胆固醇(TC)水平;动物一般状况、其他血液和血液生化指标、脏器系数、病理解剖观察均未见明显异常;停药2周后各指标与对照组相比,差异均无显著性。结论:荫风轮总苷未见有明显毒性反应及延时毒性,表明其安全性较高。更多还原

【Abstract】 Objective: To observe the acute and long term toxicity of Total Clinopodium Glycosides (TCG) in mice and rats respectively. Method: The maximal tolerance dose was tested by gastric perfusion, the death circumstance of the animals in 7 days observed; Rats was divided into control group, three groups with high, moderate and low dosage of TCG (940,470,235 mg·kg -1 /d) with repeated gastric perfusion for 4 weeks and 2 weeks after drug withdrawal. Result: The maximal tolerance dose is 8.0 g·kg -1 /d, equal to 476.19 times of the dosage used in clinic for an adult. The test groups all can shorten blood clotting time obviously, the groups with high and moderate dosage goes up the blood TP and Alb level, showing obvious difference with control group, TCG high dosage group can lower the blood TC level obviously; the indexes of general condition, other blood routine testes , blood chemical analysis, organ coefficient of rats, pathological anatomic examination were not found obvious abnormality ;There was no significant difference between the test groups and the control in all tested parameters after drug withdrawal for 2 weeks. Conclusion: TCG has no obvious toxicity responds and postpones toxicity, which indicates TCG deserves safety.更多还原