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D-氨基葡萄糖盐酸盐的制备优化
Optimization of preparation process of glucosamine hydrochloride
【摘要】 目的优化从甲壳素酸水解制备氨基葡萄糖盐酸盐的制备工艺。方法采用正交试验L9(34),优化水解工艺条件。结果以30%HCl,温度95℃,时间3h效果最佳。纯度>99.0%。结论该优化条件能得到较高产率和纯度的盐酸氨基葡萄糖。
【Abstract】 AimTo optimize the preparation process of glucosamine hydrochloride. MethodThe best hydrolytic conditions of glucosamine hydrochloride was chosen by orthogonal experimental design. ResultThe optimization conditions were HCl 30%,95℃,and 3 h.Conclusion The better yield and high purity were obtained under the conditions.
【关键词】 正交试验;
氨基葡萄糖盐酸盐;
制备工艺;
【Key words】 orthogonal design; glucosamine hydrochloride; preparation process;
【Key words】 orthogonal design; glucosamine hydrochloride; preparation process;
- 【文献出处】 安徽医药 ,Anhui Medical and Pharmaceutical Journal , 编辑部邮箱 ,2005年05期
- 【分类号】TQ464
- 【被引频次】9
- 【下载频次】595