【摘要】 以反式-对戊基环己基甲酸为原料,经酰氯化,氨解,脱水,G rignard反应四步合成乙烷类液晶中间体反式-对戊基环己基苄基甲酮.对G rignard反应合成条件进行了研究,获得了优化反应条件是:采用四氢呋喃和甲苯混合溶剂,n(C6H5CH2MgC l)∶n(C5H11C6H10CN)=1∶1.5,反应10h,总收率为41.5%.目标产物经IR和1HNMR确证其结构.更多还原

【Abstract】 Trans-p-Pentylcyclohexylbenzylketone is an intermediate to synthesize ethane′s liquid crystal.Target molecule was prepared from trans-p-Pentylcyclohexanecarboxylic acid through acylchloridation、ammonolysis、dehydration and grignard reaction.Synthesis condition of grignard reaction was researched,and the optimum reaction conditions were as follows : with tetrahydrofuran and methylbenzene as reaction solvents,n(C₆H₅CH₂MgCl)∶n(C₅H₁₁C₆H₁₀CN)= 1∶1.5,and 10h treaction time,a total yield of 41.5% was achieved.The structure of the compound was characterized by IR,¹HNMR.更多还原