【摘要】 以D＿(+)＿泛酸钙(维生素B3)为原料通过化学修饰研制出一种水难溶型维生素B3衍生物(D＿(-)＿O,O＿二硬脂酰基泛酸苄酯),产品小试收率为79%,含量高于97%.产品的熔点为22～28℃,常温下5h水中流失率小于1%.饲喂结果表明:饲料中添加水难溶型维生素B3可以提高牙鲆幼鱼的增重率.更多还原

【Abstract】 A new compound D_-O,O_benzyldistearylpantothenate was synthesized by the reaction of calcium pantothenate with benzyl chloride and stearyl chloride. The structure of the product was identified by elemental analysis, IR and¹HNMR. Stearyl chloride （0.9 mol） was added relaxedly to the solution of D_benzylstearate （123 g, 0.4 mol） in pyridine （250 mL）. The mixture was stirred for 2 h under design temperature. After evaporation of the solvent and removal of the others, D_-O,O_benzyl bistearylpantothenate（358 g） was obtained. The melting point was 22～28 ℃. [α]_D²⁰=-0.2°（DMF）. Elemental analysis: C, 73.91; H, 11.32; N, 1.44. Anal. Calcd.according to C₅₉H₉₁O₇N·0.25C₁₈H₃₆O₂: C, 74.30; H, 11.03; N, 1.53. IR: 3　330 cm^-1 （w）, 1　785 cm^-1 （s）, 1　730 cm^-1 （vs）, 1　670 cm^-1 （m）, 1　530 cm^-1 （w）, 1　490 cm^-1 （w）, 1　450 cm^-1 （m）, 1　220 cm^-1 （vs）, 720 cm^-1 （s）.¹HNMR:δ7.46～7.11（m, 5H, ArH）, 5.20～3.60（m, 7H, OCH, N—CH₂—）, 2.50～2.20（m, 6.5H, CH₂—CO）,1.50～1.10（br, 68H, —CH₂—）, 1.00～0.80（m, 13H, CH₃）. The yield of hydrophobic vitamine B₃ was 79% in laboratory and was 80% in magnified experiment. The purity was over 97%. The loss rate of hydrophobic vitamine B₃ was less than 1% in water within 24 h at room temperature. The feeding results showed that the product could increase the weight of leftege flounder parr.更多还原