【摘要】 目的 探讨长期服用茶多酚(GTP)对肝癌高危险人群免疫功能和抗氧化作用的影响。方法 以服用GTP和安慰剂满3年的1 200名肝癌高危险人群为对象,采用S-P一步染色法、MTT法和黄嘌呤氧化酶法,分别抽样检测淋巴细胞亚群、NK细胞活性和超氧化物歧化酶(SOD)。结果 服用GTP人群的CD3、CD4、CD4／CD8及NK细胞活性均显著高于服用安慰剂的对照人群(P<0.05)。CD8则明显低于对照人群(P<0.05);服药组人群血清SOD活性明显高于对照人群(P<0.05)。结论 GTP预防人类肝癌的作用机制与免疫调节功能和抗氧化作用密切相关。更多还原

【Abstract】 Objective To assess the effects of long-term taking green tea polyphenols (GTP) on the immune functions and anti-oxidation among people with high risk of suffering from liver cancer. Methods 1200 subjects with high risk of suffering from liver cancer were divided into two groups, one taking GTP and the other a placebo. Then T lymphocyte subgroups, the activity of NK cells and SOD were tested by S-P one-step staining method, MTT method and xanthine oxidase method respectively. Results The test group taking GTP had remarkably higher CD3, CD4, CD4/CD8 and NK cell activities than the control group taking a placebo (P<0. 05 ) and CD8 of the test group was obvious lower than the control group(P<0. 05 ) while serum SOD activity of the former was obviously higher than the latter (P< 0. 05). Conclnsion The action of GTP to prevent human from liver cancer has a close link to immune regulation functions and anti-oxidation action.更多还原