【摘要】 目的　探讨动脉粥样硬化性血栓性脑梗死 (ATCI)病人血清对氧磷酶 -1(PON -1)水平变化及其临床意义。方法　应用酶联免疫分析法测定 60例ATCI病人急性期和恢复期血清PON -1活性及血浆ox -LDL的浓度 ,比较轻、中、重 3型病人的PON -1活性的变化。结果　ATCI病人急性期PON -1活性显著低于健康对照者。重型AT CI病人PON -1活性显著低于轻型病人。病人血浆ox -LDL的浓度较对照组明显升高。结论　PON-1活性的降低在ATCI的发病中起一定的作用。更多还原

【Abstract】 Objective To investigate the changes of the serum paraoxonase activity in patients with atherosclerosis cerebral infarction and its clinical significance.Methods The serum PON-1 activity and ox-LDL levels were determined by ELISA from 60 patients with ATCI and 20 normal controls.Results The activity of PON-1 significantly decreased in ATCI group than in controls ,while the levels of ox-LDL were higher in patients group.Conclusion The decrease of serum PON-1 activity promoted atherosclerosis which could lead to cerebral infarction.更多还原