【摘要】 目的　探讨窒息新生儿血清总蛋白 (STP)、白蛋白 (ALB)、球蛋白 (GLO)及前白蛋白 (PA)的变化 ,并借此了解窒息对肝细胞有无损伤及其程度。方法　 4 1例窒息新生儿 ,其中轻度窒息组 2 1例和重度窒息组 2 0例 ,同期足月正常新生儿10例为对照组 ,收集其静脉血 ,检测血清STP、ALB、GLO及PA的含量。结果　与对照组相比 ,轻度窒息组血清STP和GLO含量不降低 (P >0 .0 5 ) ,而ALB及PA含量显著降低 ,差异有显著意义 (P <0 .0 1) ;与轻度窒息组和正常组相比较 ,重度窒息组血清STP、ALB、GLO及PA含量显著降低 ,差异有显著意义 (P <0 .0 1或P <0 .0 2 )。结论　新生儿窒息后肝功能可受到不同程度的损伤 ,与窒息程度密切相关 ;测定血清蛋白的含量可以作为反映肝细胞损伤的指标 ,尤以ALB及PA灵敏。更多还原

【Abstract】 Objectives: To study they changes of serum total protein(STP),albumin(ALB), globulin(GLO),and prealbumin(PA) in serum of asphyxiated newborns,and injury of liver cell in asphyxiated newborns. Methods: Forty-one mature newborns with neonatal asphyxia were divided into mild asphyxiated newborns group (n=21) and serious asphyxiated newborns group (n=20).Ten mature newborns were in non-asphyxia control group.Collected the venous blood of their and measured the concentration of STP, ALB, GLO and PA in serum. Results: There were no significent differences in STP of serum and GLO of serum in mild asphyxiated newborns compared with controls(P>0.05),the ALB level and PA level significently decreased in mild asphyxiated(P<0.01).The STP level,ALB level ,GLO level and PA level significently decreased in serious asphyxiated compared with controls and mild asphyxiated(P<0.01or P<0.02). Conclusion: In asphyxiated newborns,the liver function may be differently injured and had a positive correlation with the severity of asphyxia.serum proteins can take for the mark of liver fuction injury,especially ALB level and PA level are sensitive marks.更多还原