【摘要】 目的　探讨MR灌注成像在良性前列腺增生中的应用 ,评价血管内皮生长因子 (VEGF)和微血管密度 (MVD)与MR灌注成像各指标的相关性。方法　对临床诊断为良性前列腺增生 (BPH )的 42例患者和 3 0例健康志愿者进行MR灌注成像 (PWI) ,对BPH标本作免疫组化检测 ;分析病变灌注曲线最大线性斜率 (SSmax)、准T2弛豫率 (ΔR2 peak)与免疫组化结果 (VEGF、MVD)的相关性。结果　健康志愿者、BPH患者灌注曲线的最大线性斜率及准T2弛豫率分别为 0 .43 0±0 .0 11、2 .0 1± 0 .0 7和 3 3 .5± 3 .1、1.5± 0 .1(P <0 .0 5 )。结论　PWI可反映BPH患者MVD和VEGF表达程度 ,推测其血管生成情况。更多还原

【Abstract】 ObjectiveTo explore the preliminary application of perfusion weighted MR imaging (PWI) in benign prostatic hyperplasia (BPH), and to evaluate the correlation of PWI features with vascular endothelial growth factor (VEGF) and microvessel density (MVD). MethodsForty two consecutive patients who were diagnosed clinically of BPH and thirty healthy subjects were examined by PWI. MVD and VEGF were obtained with immuno histochemical methods. Some parameters of PWI, including the steepest slope of signal intensity time curve (SS max ) and ΔR2 *peak of lesions, were analyzed. Correlation analysis was used to determine the relation between the results of PWI and that of immuno histochemistry. ResultsIn the healty subjects, the SS max and ΔR2 *peak of perfusion curve was 0.430±0.011 and 2.01±0.07, respectively, while in BPH was 33.5±3.1, 1.5±0.1, respectively ( t =3.11, 2.23, P <0.05). ConclusionOn PWI, SS max and ΔR2 *peak can reflect MVD and VEGF express levels in BPH, implying the angiogenesis.更多还原