【摘要】 目的 :探讨肾移植受者术后早期环孢素服药后 2h全血浓度 (C2 )监测的临床意义。方法 :用特异性荧光偏振免疫法(FPIA)同步测定 5 8例肾移植受者 6 6 7对全血谷浓度C0 与C2 浓度 ,回顾性分析C0 、C2 监测在预测肾移植急排反应和不良反应中的有效性。结果 :环孢素的C2 推荐范围为 :术后≤ 1月为 110 3～ 16 4 6ng·ml-1;术后 2月为 10 98～ 15 6 0ng·ml-1;术后 3月为 934～ 12 99ng·ml-1;术后 >4月为 82 7～ 110 0ng·ml-1。结论 :环孢素的C0 与C2 都能预测不良反应和急排反应的发生 ,但C2 监测更灵敏有效。更多还原

【Abstract】 Objective: To explore the clinical role of two hour concentration(C 2) of CsA in Chinese renal transplant recipients.Method: The concentration of 667 couple of C 2 and C 0 was determined by FPIA method at same time.The effectiveness in predicting the acute rejection and side effects was retrospectively analyzed.Result: Both C 2 and C 0 could predict the acute rejection and side effects of C 2. The satisfactory immunosuppressive concentration was found as follow:C 2 was 1 103～ 1 646 ng·ml -1 within the first month after transplantation, C 2 was 1098～ 1560 ng·ml -1 in the second month, C 2 was 934 ～ 1299 ng·ml -1 in the third month, C 2 was 827～1100 ng·ml -1 since then.Conclusion: Both C 2 and C 0 can predict the acute rejection and side effects, but C 2 is more effective.更多还原