【摘要】 目的　研究杀扑磷原药的急性和亚慢性毒性及致突变性 ,求出最大无作用剂量。方法　按照GB 15 670 -1995《农药登记毒理学试验方法》和GB 15 193 -94进行试验。结果　雌性大鼠LD50 为 3 8 3mg/kg ,雄性大鼠为 3 1 6mg/kg。小鼠骨髓多染红细胞微核试验和小鼠精子畸变试验均为阴性。大鼠亚慢性经口毒性试验显示 ,11 67mg/kg和 3 5 0 0mg/kg饲料组全血胆碱酯酶活力抑制明显 ,3 5 0 0mg/kg饲料组 ,雌性大鼠总摄食量明显减少。结论　杀扑磷的最大无作用剂量为 :雌性大鼠(1 2 6± 0 0 8)mg/ (kg·d) ,雄性大鼠 (0 40± 0 0 4)mg/ (kg·d)。更多还原

【Abstract】 To study the acute and subchronic toxicity and mutagenicity of methidathion and find out its NEL. Experiments were carried out according to GB 15670-1995 "Methods of Toxicological Experiment on Pesticide Registration" and GB 15193-94. LD50 was 38.3 mg/kg in female mice and 31.6 mg/kg in male mice. The test on micronucleus and sperm shape abnormality in mice both showed negative. The subchronic test of methidathion showed significant inhibition on cholinesterase activity in the 11.67 mg/kg food group and 35.00 mg/kg food group. The food intake of the 35.00 mg/kg group significantly decreased. [Conclusion] The NEL of methidathion was (1.26±0.08) mg/(kg.d) for female mice and (0.40±0.04) mg/(kg.d) for male mice.更多还原