【Abstract】 In the treatment of AIDS the highly-active anti-retroviral therapy(HAART) is potential and effective,but after one year of practice,many disadvantages appeared:After withdrawal of medication(short or long term) the plasma virus level rapidly rebound to that of before treatment which existed originally in the lymph nodes;there are different types of HIV susceptible cells,some of them could not be reached or being insensitive by anti-retroviral therapy(ART);ART agent’s target is designed against different life cycle.they can Iower the plasma VL IeveI to undetectable Ievel.but they cannot revive the destroyed immune system to normal immune function.as soon as withdrawaI occurred.the body still couldn’t yield immune response to HIV;the original combination using of ART is to clear the virus and prevent the drug tolerance,but under the pressure of highdosage of ART,the appearance of tolerance is inevitable.After HAART treatment.4 kinds of treatment occurred:40% patients after effective inhibit plasma VL.immune reconstitution appeared;40%patients VL does not reduce.but CD4 gradually increase;5% patients VL began to lower,but CD4 without recovery:Completely ineffective,without any improvement both in VL and CD4 count.The tolerance of ART and immune impairment are 2 important factors.the latter is more important.Lymphocyte is activated against HIV replication.including HIV specific cytotoxic action.cytokine secretion,etc.But the large amount of infected cells,the specific viral gene and phenotype variation would cause the activated lymphocyte unable to clear-up the HIV and HIV-infected cells,the specific cytotoxic lymphocyte(CTL)and CD4 T helper inactivated.Three kinds of medicine were being used:Immune cell activator(IL-2,IFN-γ),immunosuppressor(cyclosporin A)and virus replication inhibitor(IL-10,MIP-l α)to activate macrophage and promote immune response.TCM immuno-modulatory effect in treating AIDS:Immune-based intervention is regression of natural medicine, it re-evaluates the effect of organic immune system in treating HlV/AIDS.which coincides with holistic approach and syndrome differentiation theory in TCM.Astragalus membanaceus contains many jmmuno-modulatory active substances,which could reverse the immunosuppressor induced immunosuppression,promote the production of cytotoxic T lymphocytes.The polysaccharide in Lycium barbarum and Ligusticum lucidum could reproduce the splenic activating cells,displays mitogenoid action.And the polysaccharide of Angelica sinensis,Embellatus polyporus could stimulate lymphocyte reproduction.Ginsenoside and polysaccharide could obviously induce IL-2 and its gene expression.Some compound recipes(802、806、809) could increase plaque forming cells(PFC),serum rosette formling cells(SRFC) and delayed-type hypersensitivity(DTH),promote IL-1 and IL-2 production,and increase the CD4 cell count and reverse the CD4/CD8 ratio.Zhongyan-2 could raise CD4 celI count for 50 cells/mm 3,IL-2 and IFN have increasing tendency,Neopterin and β 2 microglobulin also showed elevation.更多还原