【摘要】 目的 :观察肠炎康对溃疡性结肠炎的疗效和作用机理。方法 :采用三硝基苯磺酸法制备大鼠实验性溃疡性结肠炎模型 ,观察各组结肠病理损伤、IL -1β、TNF -α、SOD、MDA等指标的变化 ;并观察肠炎康对小肠推进运动、炎症和疼痛的影响。结果 :肠炎康能减轻溃疡性结肠炎的病理损伤 ;显著降低溃疡性结肠炎大鼠血清IL -1β、TNF -α、结肠组织MDA含量 ,而提高SOD含量 ;能明显降低小肠内墨汁推进率 ,减慢小肠蠕动速度 ;能降低毛细血管的通透性 ,具有一定的抗炎作用 ;对化学因素引起的疼痛有较好的镇痛作用。结论 :肠炎康有减轻结肠炎症损伤、减轻氧自由基的损害、解痉、抗炎镇痛的作用。更多还原

【Abstract】 Objective:To investigate the effects and mechanism of Changyankang Decoction on chronic ulcerative colonitis. Methods: The rat ulcerative colonitis model was made with TNBS, the pathology of colon ,IL-1β,TNF-α,SODand MDA were measured in all groups, and the effect of the drug on movement of small intestine, inflammation and pain were observed. Results:The drug could alleviate pathologic damage of ulcerative colonitis; debase IL-1β,TNF-αin serum and MDA in colon, increase SOD in colon; depress pushing rate of ink in small intestine, reduce penetration of capillary, resist inflammation; lessen the pain arosed by chemicals. Conclusion: Changyankang Decoction could alleviate pathologic damage and free radical damage of ulcerative colonitis, and is effective to intestine spasm, inflammation and pain.更多还原