【摘要】 目的　测定初次确诊为糖尿病患者的血清瘦素水平 ,探讨瘦素与体重指数 ,血糖、甘油三脂、胆固醇和空腹胰岛素的关系。方法　受试者精确测量身高、体重、计算体重指数 (BMI) ,同步检测空腹血糖(FPG) ,胰岛素 (Fins) ,胆固醇 (CH)、甘油三酯 (TG) ,放射免疫法 (RIA)测定血清瘦素 (Leptin)水平。结果　糖尿病组与对照组比较瘦素水平无显著性差异 (P >0 0 5 ) ;无论是糖尿病组还是对照组 ,肥胖者的瘦素水平与非肥胖者的瘦素水平相比均有显著性差异 (P <0 0 1) ;女性的瘦素水平明显高于男性 (P <0 0 1) ;相关分析显示 ,瘦素与体重指数 (r=0 44 0 6　P <0 0 1)显著相关 ;瘦紊与胰岛索 (t =0 2 64 4　P <0 0 5 )显著相关 ;瘦素与FPG (r=0 1112　P >0 0 5 )、TG (r=0 0 0 0 8P >0 0 5 )、CH (r=0 0 194P >0 0 5 )无相关性。结论　血清瘦素水平与BMI显著相关 ,显示存在瘦素抵抗 ;瘦素与胰岛素有相关性 ,提示两种激素间存在一定的内在联系更多还原

【Abstract】 Objective To determine the serum concentration of leptin in patients with de novo diabetes mellitus (DM) and to evaluate the related factors.Methods Height, weight and body mass index (BMI) of patients were measured, and fasting plasma glucose (FPG), insulin, cholesterol (CH) and triglyceride (TG) were detected simultaneously. Radioimmunoassay (RIA) was applied to determine serum level of leptin.Results There was no significant difference on serum leptin level between DM group and control group; while, where were significant differences between obese and non obese subjects or between women and men in both two groups (P<0 01). In addition, the serum level of leptin were significantly correlated with BMI (r=0 4406, P<0 01) and insulin (r=0 2644, P<0 05) but not FPG (r=-0 1112, P> 05), TG (r=0 0008, P> 05)and CH (r=-0 0194, P>0 05).Conclusions Serum leptin has significant correlation with BMI in patients with diabetes, which indicate that leptin resistance may exist in de novo diabetes mellitus patients. And this results also indicate that there is some inner relationship between leptin and insulin.更多还原