【摘要】 目的 :观察冰片对大鼠下丘脑组胺、5 羟色胺含量的影响。方法 :通过给大鼠灌服不同剂量的冰片 ,用高效液相色谱 电化学检测的方法分别测定给药前及给药后不同时间点大鼠下丘脑组胺和 5 羟色胺的含量 ,研究冰片对组胺和 5 羟色胺含量的影响。结果 :大鼠服冰片后下丘脑的组胺含量均比给药前组增高 ,中剂量给药后 2 0min组与给药前组比较组胺含量显著升高 (P <0 0 1) ,中剂量给药后其它各组、高剂量给药后 4 5min组、低剂量给药后 2 0min、4 5min组组胺含量显著高于给药前组 (P <0 0 5 ) ;大鼠服冰片后下丘脑 5 羟色胺含量变化如下 :高剂量给药后各组 5 羟色胺的含量均比给药前组显著升高 (P <0 0 5或P <0 0 5 ) ;中、低剂量给药后 5min、2 0min、4 5min三组的 5 羟色胺含量显著升高 (P <0 0 5或P <0 0 1)。结论 :冰片可升高大鼠下丘脑组胺和 5 羟色胺的含量更多还原

【Abstract】 Objective: To observe the effect of borneol on level of HA and 5-HT in rat’s hypothalamus Methods: The levels of HA and 5-HT in rat’s hypothalamus were determined before and after p o with different amount of borneol by high performance liquid chromatography with electrochemical detection (HPLC-ECD), and the borneol’s effect on the levels of HA and 5-HT was also studied Results: The level of HA in rat’s hypothalamus after different dose of borneol were higher than before administration The level of HA in 20 min group after middle dose increased significantly comparing with before administration(P<0 01), the others of group after middle dose, the 45 min group after high dose, the 20 and 45 min after low dose were also increased significantly than before administration(P<0 05) After different dose of borneol, the level of 5-HT in rat’s hypothalamus changed as follows: the level of 5-HT after high dose were higher than before administraton (P<0 05或P<0 01);the level of 5-HT after 5, 20 and 45 min of middle and low dose incrased significantly(P<0 05或P<0 01) Conclusion: Borneol could increase the levels of HA and 5-HT in rat’s hypothalamus更多还原