【摘要】 目的：观察氟比洛芬酯与酮洛芬对照治疗术后及癌性疼痛患者的有效性。方法：日本36家医院共入选腹部术后患者224例，癌性疼痛患者163例，随机分为氟比洛芬酯组192例与酮洛芬组195例，分别用氟比洛芬酯与酮洛芬安慰剂和酮洛芬与氟比洛芬酯安慰剂。氟比洛芬酯及其安慰剂5mL静脉内注射，酮洛芬及其安慰剂每瓶用2．5mL溶液溶解臀部肌内注射。结果：可评价病例氟比洛芬酯组对术后疼痛111例患者改善率为73．9％，高于酮洛芬组(n=109)的66．1％，但2组差异无显著性(P>0．05)；药效持续时间氟比洛芬酯组比酮洛芬组延长(P<0．05)。氟比洛芬酯组癌性疼痛(n=77)改善率为77％，高于酮洛芬组(n=81)的59．3％(P>0．05)，药效持续时间氟比洛芬酯组比酮洛芬组延长(P<0．05)。结论：在治疗术后疼痛和癌性疼痛时，氟比洛芬酯的疗效与酮洛芬相近，但镇痛时间明显延长。更多还原

【Abstract】 Objective:To compare the effectiveness of flurbiprofen axetil injection for the treat-ment of post-surgical and carcinous pain to ketoprofen. Methods:224 patients with post-surgical pain and 163 patients with carcinous pain were randomized to receive an intravenous bolus of flurbiprofen axetil injection or matching placebo at 5mL( n = 192), or im ketoprofen or matching placebo at 2.5mL (n = 195).Results:Pain relief in the flurbiprofen axetil injection group was not significantly more superior than in ketoprofen group (P >0. 05). However, the maintenance period in pain relief in flurbiprofen group was significantly longer than in ketoprofen group (P < 0.05 ). Conclusion: Flurbiprofen axetil injection shows the equivalent efficacy and longer maintenance in the post-surgical and carcinous pain relief to ketoprofen.更多还原