【摘要】 目的：合成吲哚美辛衍生物，以寻找新的对胃肠道毒不良反应更小的非甾体抗炎药。方法：吲哚美辛 与卤代烃、硝基苄醇、硝基苄基氯等化合物进行缩合以及硝酸酯化反应，制备相应结构的衍生物。结果与结论：合 成的6个化合物中，化合物3a，3c和5b的抗炎活性明显高于吲哚美辛。更多还原

【Abstract】 Objective:To search for new NSAIDs with higher efficacy and lower toxicity. Methods : Indomethacin derivatives were prepared from halohydrocarbons, nitrobenzyl alcohol and netroben zychloride by reactions of condensation and esterfication. Results and Conclusion: 6 new compounds have been synthesized,among them compound 3a,3c and 5b had an anti-inflammatory activity comparable to or higher than indornethathcin.更多还原