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木犀草素β-环糊精包合物的研究

Preparation of β-cyclodextrin inclusion compound of luteolin

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【作者】 李锦莲李秀玲于德成房心连盖宏旺

【Author】 LI Jin-Han,LI Xiu-ling,YU De-cheng,FANG Xin-lian,GAI Hong-wang ( College of Chemistry and Pharmacy ,Jiamusi University ,Jiamusi 154007, China )

【机构】 佳木斯大学化学与药学院佳木斯大学化学与药学院 佳木斯 154007佳木斯 154007佳木斯 154007

【摘要】 目的:研究木犀草素β-环糊精包合物的制备工艺。方法:采用饱和水溶液法进行包合,用红外光谱法、X-衍射法、差热扫描分析法等对包合物进行了验证,并测得其包合率及溶解度。结果:包合物确已形成,收率为88.32%,包合物溶解度为88.25mg·L-1,木犀草素溶解度为2.160mg·L-1。结论:该法包合效果较好,包合物提高了木犀草素的溶解度。

【Abstract】 Objective:To prepare β-cyclodextrin inclusion compound of luteolin. Methods: Satu-rated aqueous solution was adapted to achieve inclusion. The inclusion compound obtained was evaluat-ed by IR absorption spectrophotometry, X-ray diffraction technique, and differential scanning calori-metric analysis and its inclusion rate and solubility were also measured. Results: The yield of β-cy-clodextrin inclusion compound of luteolin was 88.32% with a solubility of 88.25mg·L-1(solubility of luteolin=2. 160mg·L-1). Conclusion: The solubility of luteolin is significantly improved by β-cyclodextrin inclusion.

【关键词】 木犀草素β-环糊精包合物溶解度
【Key words】 luteolinβ-cyclodextrininclusionsoluhility
  • 【文献出处】 中国新药杂志 ,Chinese New Drugs Journal , 编辑部邮箱 ,2004年06期
  • 【分类号】R283
  • 【被引频次】22
  • 【下载频次】351
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