【摘要】 目的 :探讨苦参素联合α 干扰素治疗慢性丙型肝炎的临床疗效。方法 :将慢性丙型肝炎患者 72例随机分为治疗组和对照组各 3 6例 ;治疗组给予苦参素联合干扰素 αlb 3MU ,对照组单用干扰素 αlb。两组疗程均 2 4周。观察治疗前后肝功能、HCVRNA、肝纤维化指标变化情况。结果 :两组患者肝功能均有明显改善 ;治疗组和对照组HCVRNA阴转率分别为 5 8 3 %和 3 3 3 % ,两组患者血清透明质酸 (HA)、Ⅲ型前胶原肽 (PⅢP)、Ⅳ型胶原 (C Ⅳ )和层粘蛋白 (LN)浓度与治疗前相比明显下降 ,差异均有显著性意义 (P <0 0 1) ;治疗组在HCVRNA阴转率、HA、C Ⅳ的改善方面优于对照组 (P <0 0 5 )。结论 :苦参素联合干扰素 αlb治疗慢性丙型肝炎能有效改善肝功能 ,在抗病毒方面有协同作用 ,并能增强抗肝纤维化的效果更多还原

【Abstract】 Objective:To investigate the effect of Kurorinone injection with interferon α in the treatment of chronic hepatitis C. Methods:72 patients with chronic hepatitis C(CHC) were randomly divided into two equal groups. Patients of the treatment group were given each 0.6 of Kurorinone injection, I.Vggt.q.d. and 3MU of interferon α (IFN-α). I.M.while those of the control group were given each 3MU of IFN-α alone. The course of treatment in both groups lasted 6 months. Changes in liver function, serum levels of HCV and indices of hepatic fibrosis before and after the treatment were kept under observation.Results:Liver funtion of patients in both groups was found to improve dramatically.Indices of hepatic fibrosis including serum concentrations of hyalurorhic acid(HA), procollagen type Ⅲ (PⅢP), collagen type Ⅳ(CⅣ) and laminin(LN) were markedly lowerd. The differences were significant in both groups when compared with those parameters before the treatment(P<0.01). The rates of serum turning negative for HCV RNA were 58.3% and 33.3% in the treatment group and control group, respectively(P<0.05). Serum levels of HA and CⅣ Were lower in the treat ment group than in the control group (P<0.05) after the treatment. Conclusion: Kurorinone injection combined with IFN-α was found to improve liver function, exert synergistic antiviral effect and promote the process of antifibrosis in the treatment of chronic hepatitis C.更多还原