【摘要】 目的探讨骨肉瘤中c-myc蛋白表达强度与临床、病理特征的关系。方法采用SABC免疫组化方法检测42例骨肉瘤中的c-myc蛋白的表达强度,并根据病理分型和Enneking外科分期进行分组比较。结果c-myc蛋白在髓内高分化型骨肉瘤中的表达强度低于成软骨细胞型和成纤维细胞型骨肉瘤(P<0.05)。c-myc蛋白在ⅡA期骨肉瘤的表达强度低于ⅡB期和Ⅲ期(P<0.05)。结论c-myc蛋白的表达强度可以作为判断骨肉瘤的分化程度和外科分期的参考指标。更多还原

【Abstract】 Objective: To evaluate the correlation of c-myc protein expression with clinical and pathological features. Methods: The expression intensity of c-myc protein were investigated by using SABC immunohistochemical method in 42 their pathological features and Enneking′s surgical stages of osteosarcoma. Every group was compared with each other. Results: The expression intensity of c-myc protein in intraosseous well-differentiated osteosarcoma was lower than in fibroblastic and chondrouastic osteosarcoma (P <0.05). the expression intensity of c-myc protein in IIA stage of osteosarcoma was lower than in ⅡB and Ⅲ stage of osteosarcoma (P <0.05). Conclusion: The intensity of c-myc protein expression is a referential index of the Enneking′s surgical stage and the defferential degree of osteosarcoma.更多还原