【摘要】 目的该文将30例老年糖尿病患者进行颈动脉超声检测和选择素P,L,E测定,探讨2型糖尿病患者颈动脉粥样硬化与选择素变化的关系。方法颈动脉测定采用惠普采色多普勒仪,观察颈总动脉,颈内动脉和颈动脉分叉部的图像。选择素P,L,E测定采用ELISA法。结果该组糖尿病组Ⅱ期、Ⅲ期斑块占90%,而高血压伴2型糖尿病组Ⅱ期斑块占30%,Ⅲ期斑块占70%。与对照组比较提示糖尿病患者颈动脉斑块患病率显著高于对照组;而糖尿病组与糖尿病并高血压之间斑块发生率差异不明显。选择素在动脉粥样硬化斑块形成过程中起重要作用。在糖尿病伴高血压患者选择素P,L,E均较糖尿病组升高。结论老年糖尿病患者均有不同程度的颈动脉粥样硬化,血浆选择素也有不同程度升高,选择素升高可预示2型糖尿病并发心血管并发症风险增加。更多还原

【Abstract】 Objective: To investigate the relationships between plaque in carotid artery and selectin P.L.E in old patients with type 2 diabetes mellitus. Methods: B-mode ultrasound examination of common carotid artery (CCA) and internal carotid artery (ICA), bifurcations (CBS) in 30 cases. Selectin P.L.E were measured by using the enzymc linked immunosorbent assay (ELISA) methods. Results: The results showed the diabetes groups plaque of Ⅱ, Ⅲ type take up 90 percent, the hypetension with diabetes groups plaque of Ⅱ type take up 30 percent, Ⅲ type take up 70 percent. Sufferer ratio of plaque in carotid artery with diabetes was significantly higher than that in control group. Selectin P.L.E in diabetes with hypetension group were significantly higher than that diabetes group. Conclusion: Old patients with type 2 diabetes mellitus may have arteriosclerosis of carotid artery and selectin may increase to some extent. Seletin family correlates with plaque of carotid artery type 2 DM.更多还原