【摘要】 目的为提高患者激活自身免疫细胞抗肿瘤活性,且杀灭胸水癌细胞的作用,达到减少恶性胸水及减轻病人痛苦。方法确诊为恶性胸水的患者共56例,采取简单随机分成两组,即沙培林、顺铂联合用药组与顺铂组,每组28例。两组患者在胸腔闭式引流放尽胸水后,分别注入不同药物处理,比较两种处理方法对消胸灌注药次数有无差别。结果两组患者消胸水用药灌注次数有差别(P≤0.05)。以沙培林、顺铂林联合用药灌注组优于单纯顺铂灌注组。结论沙培林、顺铂林联合用药对激活免疫细胞抗肿瘤活性、杀灭癌细胞,促进胸膜粘连,既达到减少恶性胸水,又有提高患者抗病能力的作用。更多还原

【Abstract】 Objective: To stimulate the immunocytes in patients to resist the cancer, in order to decrease malignant hydrothorax, and to alleviate the patients′ pain. Methods: The patients who were diagnosed as malignant hydrothorax, were divided into two teams randomly. One team was treated by DDP and the other team was treated by sapylin and DDP. After completely depleting the exudates, the patients of two teams accepted the different medicines, by perfusions to the thorax, observing if there were different influences of decreasing hydrothorax and the times of the perfusion to the thorax. Results: There are prominent differences in decreasing hydrothorax and the times of the perfusion to the thorax (P≤0.05). Perfusions to the thorax of saplin and DDP are better than perfusions of saplin only. Conclusions: Perfusions to the thorax of saplin and DDP are effective to stimulate the immunocytes to resist cancer and to kill the cells of cancer. It not only reduces the chance of the conglutination of pleura but also increases patients’ ability to resist the disease.更多还原