【摘要】 目的探讨病毒性肝炎肝硬化与胆汁性肝硬化之间的血脂、载脂蛋白变化及其临床意义。方法检测35例慢性乙型病毒性肝炎肝硬化、21例胆汁性肝硬化病人的血浆胆固醇(CHOL)、甘油三脂(TRIG)、高密度脂蛋白(HDL)、载脂蛋白A1(APOA1)、载脂蛋白B100(APOB100)、总胆红素(TBIL)、凝血酶原活动度(PTA),并与正常人相比较。结果胆汁性肝硬化病人的CHOL、TRIG和APOB100明显升高,而肝炎后肝硬化病人却反有明显下降,统计学差异显著(P<0.01);两组病人的HDL、APOA1都有轻度下降,两者的下降幅度相差不明显;所有病人TBIL均明显升高,以胆汁性肝硬化病人尤为明显,统计学差异显著;两肝硬化组病人的PTA比对照组明显降低,以肝炎后肝硬化组尤甚,统计学差异显著。结论肝炎后肝硬化与胆汁性肝硬化血脂、载脂蛋白的变化有一定差异,可作为临床诊断、鉴别诊断的参考依据。更多还原

【Abstract】 Objective: To study the variation of lipidemia and apolipoprotein in posthepatitic cirrhosis and biliary cirrhosis. Methods: The plasma cholesterol (CHOL), triglyceride (TG), high-density lipoprotein (HDL), apolipoprotein A1 (APOA1), apolipoprotein B100 (APOB100), total bilirubin (TBIL) and prothrombin activity (PTA) of 35 patients with posthepatitic cirrhosis and 21 patients with biliary cirrhosis and 31 healthy persons as control group were determined and compared. Results: Compared with the control group, the levels of CHOL and TRIG and APOB100 in patients with biliary cirrhosis were significantly increased, but those in patients with posthepatitic cirrhosis were significantly decreased. The levels of TBIL in all patients were significantly increased, especially in patients with biliary cirrhosis. The levels of PTA were significantly decreased, especially in patients with posthepatitic cirrhosis. No difference was found in their levels of HDL and APOA1. Conclusions: The manifestation of lipidemia and apolipoprotein between the posthepatitic cirrhosis and biliary cirrhosis had significant difference and can be regarded as reference criteria for diagnosis and differentiation.更多还原