【摘要】 目的探讨喉癌组织Bcl-2和Bax基因蛋白表达与喉癌发生、发展的关系。方法采用免疫组化SP法测定5例正常人声带组织和73例喉癌组织标本中Bc1-2和Bax基因蛋白表达。结果喉癌组织中Bc1-2基因蛋白表达阳性检出率45.2%,喉癌组织中Bax基因蛋白表达阳性检出率60.3%,与正常人相比,差异均无显著性(>0.05)。喉癌组织中Bcl-2和Bax基因蛋白的表达呈明显的负相关关系,值-0.71,<0.05。结论喉癌组织中Bcl-2和Bax基因蛋白表达的失调可能与喉癌的发生、发展有关。更多还原

【Abstract】 Objective: To study the relationship between expression of Bcl-2 and Bax in laryngeal carcinoma. Methods: Using monoclonal antibody for Bcl-2 and Bax gene protetin, 33 cases of laryngeal carcinoma were stained by SP immunohistochemistry. Results: The Bcl-2 and Bax positive rates of laryngeal carcinoma were 45.2% and 60.3% respectively. There was significant relationship between expression of Bcl-2 and that of Bax in laryngeal carcinoma. Conclusions: There is intimate relationship between abnormal expression of Bcl-2 and Bax and laryngeal carcinoma.更多还原