【摘要】 目的探讨胸腺瘤合并重症肌无力(MG)扩大根治术术式的疗效。方法该院在1996～2002年共收治胸腺瘤合并MG者146例,采用了扩大根治术切除胸腺及前纵隔脂肪结缔组织,随访0.5～7.0年,复习文献对比,经统计学处理。结果术后并发重症肌无力危象39例,94例完全缓解,术后停用抗胆碱酯酶(吡啶斯的明)药物治疗,明显改善29例,改善15例,无效3例;围术期死亡2例,远期死亡1例。病理检查,发现前纵隔脂肪内异位胸腺19例。结论扩大根治术治疗胸腺瘤合并MG,术后症状改善率提高,远期存活率高,能显著提高胸腺瘤合并MG的手术效果。更多还原

【Abstract】 Objective: To investigate the effect of thymomas with myasthenia gravis(MG) treated by extensive radical resection. Methods: We applied extensive radical resection including the thymus gland and fat-connective tissue in anterior mediastinum to cure thymomas with myasthenia gravis for 146 cases from 1996 to 2002, and followed up for 0.5～7 years. Statistical analysis was made after reviewing the literatures. Results: 39 patients suffered from postoperative myasthenia gravis crisis, 94 patients got completely remission and stopped using anticholinesterase (Pyridostigmine Bromide), obvious amelioration was found in 44 cases, inefficiency in 3 cases; 2 cases died postoperation, 1 case died after long time. 19 dystopy thymus glands were determined in fat tissues in anterior mediastinum by pathologic study. Conclusions: Extensive radical resection is effective in treating thymomas with myasthenia gravis, with a high successful symptom ameliorative rate and long-term survival rate.更多还原