【摘要】 目的 :探讨大肠癌中癌基因 C- myc和抑癌基因 p16的表达及相关性。方法 :采用免疫组织化学 SP法检测78例大肠癌组织、2 0例癌旁组织和 2 0例大肠腺瘤中 C- myc和 p16的表达 ,并分析它们之间的相关性。结果 :大肠癌中C- myc表达率最高 ,p16表达率最低 (P<0 .0 5 ) ;C- myc阳性表达和 p16阴性表达与大肠癌的临床分期、分化程度、淋巴结转移和远隔转移密切相关 (P<0 .0 5 ) ;C- myc和 p16之间存在明显的相关性 (P<0 .0 5 )。结论 :C- myc与 p16表达具有协同性 ,C- myc的表达上调与 p16失活在大肠癌发展中起关键作用。更多还原

【Abstract】 Objective:To Study the expressions of C-myc and p16 in colorectal carcinoma and their correlation.Methods:The expressions of C-myc and p16 in 78 colorectal carcinoma, 20 juxtacancerous tissues and 20 adenoma of colon were de tected by immunohistochemistry. Then the correlation of them was analyzed. Results:The positive-expression rate of C-myc was the highest, and the negative-ex pression rate of p16 was the lowest in colorectal carcinoma(P<0 .05). The positive-expression of C-myc and the negative-expression of p16 w ere closely related to clinical staging, degree of differentiation, lymph-node metastasis and distant metastasis of colorectal carcinoma(P<0.0 5). There was a relationship between C-myc and p16 (P<0.05). Conclusion:C-myc was in coordination with p16. The up-regulated C-myc and inact ivated p16 should play a crucial role in the development of colorectal carcinoma.更多还原