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顶端动脉瘤的血流动力学数值模拟压力分析

Heamodynamic numerical simulation and pressure analysis of intracranial terminal aneurysms

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【作者】 陈旭东胡继良吴耀晨杨新健

【Author】 CHEN Xudong, HU Jiliang, WU Yaochen, et alDepartment of Neurosurgery, the Second Affiliated Hospital of Jinan University, ShenZhen 518020, China

【机构】 暨南大学医学院第二附属医院神经外科北京市神经外科研究所 广东深圳518020广东深圳518020北京100050

【摘要】 目的探讨顶端动脉瘤的血流动力学特点,分析动脉瘤的生长、破裂的可能机制。方法采用计算瘤体力学(CFD)软件结合顶端动脉瘤的医学影像,对动脉瘤内血液流动行数值模拟。结果流场压力呈周期性变化,压力剧烈变化的时间窗为0~0.62T (T为周期),与速度剧烈变化时间窗一致;动脉瘤内各处压力周期变化与流场的周期变化一致;每一个具体的时刻,流场压力分布不均衡。结论压力是动脉瘤破裂的危险因子之一,压力急剧变化的时间窗是0~0.62T,与流场速度急剧变化窗一致,是动脉瘤破裂的的危险窗。每一个时刻动脉瘤流场内压力分布不均衡。CFD数值模拟是一种反映动脉瘤血流动力学较好的方法,能为动脉瘤的病理生理机制和临床治疗提供较好的帮助。

【Abstract】 Objective To investigate the hemodynamic characteristics of intracranial terminal aneurysms and analyze the possible mechanism of growth and rupture of intracranial aneurysms. Methods The images of intracranial terminal aneurysms are handled by some image processing software. The profile meshed by some computational fluid dynamics (CFD) software is used to simulate the blood flow within aneurysm. Results From the beginning to the 0.62T in each cardiac cycle, the pressure has a sharp change. The duration is coincidence with the time velocity acutely changes. The periodical change of pressure in aneurysm is consistent to the pressure change of whole flow field. At any moment, the pressure is not the same in whole flow field. Conclusion Pressure is one of risk factor, which will make the aneurysm rupture. During the period of 0 to 0.62T, both pressure and velocity have a sharp change. The duration of 0 to 0.62T is a risk time window for aneurysm rupture. CFD simulation can provide key homodynamic information for pathophysiological mechanisms and clinical treatment of terminal intracranial aneurysms.

【基金】 国家自然基金委员会(30200289);北京市自然基金委员会资助项目(7022008);北京市科委资助项目(H020820950130)
  • 【文献出处】 中国微侵袭神经外科杂志 ,Chinese Journal of Minimally Invasive Neurosurgery , 编辑部邮箱 ,2004年05期
  • 【分类号】R739.4
  • 【被引频次】6
  • 【下载频次】100
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