【摘要】 〔目的〕探讨 2 0 0 0年 7月至 2 0 0 3年 6月期间我院患者分离的铜绿假单胞菌和不动杆菌对 11种常用抗生素耐药性。〔方法〕采集患者痰、血、尿及其它标本进行铜绿假单胞菌和不动杆菌培养、鉴定及药敏试验。〔结果〕我院分离的铜绿假单胞菌和不动杆菌主要来自呼吸道标本 ;在 2 0 0 0年 7月 -2 0 0 3年 6月期间 ,分离的 491株铜绿假单胞菌对 11种抗生素的合计敏感率在 80 % -90 %之间的抗生素只有哌拉西林 他唑巴坦 ,70 % -80 %之间的抗生素有头孢他啶、环丙沙星、亚胺培南和左旋氧氟沙星 ,<60 %的抗生素有氨曲南、庆大霉素、妥布霉素、替卡西林、头孢曲松和头孢噻肟。 14 8株不动杆菌对 11种抗生素的合计敏感率在 80 % -90 %之间的抗生素有亚胺培南和哌拉西林 他唑巴坦 ,70 % -80 %之间的抗生素有环丙沙星和左旋氧氟沙星 ,<60 %的抗生素有头孢他啶、氨曲南、庆大霉素、妥布霉素、替卡西林、头孢曲松和头孢噻肟 ;在 2 0 0 0年 7月 -2 0 0 3年 6月期间铜绿假单胞菌多重耐药率合计为 2 6.2 7% ,不动杆菌多重耐药率合计为 2 6.3 5 %。〔结论〕铜绿假单胞菌和不动杆菌对绝大多数抗生素耐药性呈逐年上升趋势 ,通过对耐药性监测研究使我们提高抗生素耐药性问题的认识 ,为抗生素使用和调控提供基础。更多还原

【Abstract】 Objective To investigate the drug resistance of P. aeruginosa and Acinetobacter spp isolated from the patients in our hospital from July 2000 to June 2003 to 11 common antibiotics.〔Methods〕 Sputum, blood, urine and other specimens were collected from the patients and incubated for isolation of P. aeruginosa and Acinetobacter spp and drug resistant test.〔Results〕 The respiratory tract was the commonest source of P.aeruginosa and Acinetobacter spp.Of the 491 isolated strains of P.aeruginosa,80% to 90% were susceptible to piperacillin-tazobactam,70%-80% to ceftazidime,ciprofloxacin,imipenem and levofloxacin, <60% to aztreonam,gentamicin,tobramycin,ticarcillin,ceftriaxone and cefotaxime.Amongst the 148 isolated strains of Acinetobacter spp,80%-90% were susceptible to imipenem and piperacillin-tazobactam,70%-80% to ciprofloxacin and levofloxacin, and <60% to ceftazidime,aztreonam,gentamicin,tobramycin, ticarcillin,ceftriaxone and cefotaxime.Meanwhile,26.27% of the isolates of P.aeruginosa and 26.35% of the isolates of Acinetobacter spp were multidrug resistant.〔Conclusions〕The drug resistant rates of P. aeruginosa and Acinetobacter spp to antibiotics are slowly increasing. Reasonable use of antibiotics based on laboratory test is important in clinical practice.更多还原