【摘要】 【目的】观察奥美拉唑及吗丁啉加中药降逆汤治疗反流性食管炎的疗效及对胃动素、胃泌素的影响。【方法】将120例患者随机分成中药治疗组(降逆汤,n=40),西药治疗组(奥美拉唑及吗丁啉,n=40)和中西医结合治疗组(奥美拉唑及吗丁啉加中药降逆汤,n=40),疗程4周,观察治疗前后症状、胃镜检查,并测定血清胃动素及胃泌素的含量变化。【结果】中西医结合组的疗效(有效率97.5%)明显高于单用中药组(75%)或单用西药组(80%);患者的血清胃动素犤(182.6±43.9)pg/mL犦与胃泌素犤(99.2±31.7)pg/mL犦水平明显低于正常对照组犤(326.6±58.4)pg/mL,(163.1±28.7)pg/mL犦;3种疗法都能升高血清胃动素与胃泌素水平,而以中西医结合组的作用最好,胃动素与胃泌素平均升高110.9pg/mL和37.7pg/mL,优于单用中药组(27.6pg/mL和17.5pg/mL)或单用西药组(74.6pg/mL和21.7pg/mL)。【结论】奥美拉唑及吗丁啉和中药降逆汤是治疗反流性食管炎的有效药物,中西医结合疗法可进一步提高对反流性食管炎的疗效,促进胃肠道的动力。更多还原

【Abstract】 To investigate the effects of combination of omeprazole and motilium with Jiangni Decoction on reflux esophagitis and on motilin and gastrin. 120 cases were randomly divided into three groups Chinese medicine group(Jiangni Decoction n=40),western medicine group(omeprazole and motilium ,n=40), and combination therapy group(Jiangni Decoction, omeprazole and motilium ,n=40). All cases were treated for 4 weeks. The symptoms and gastroscopic feature were observed and recorded. Serum levels of motilin and gastrin were measured before and after treatment. The curative effect of combination therapy(effective rate 97.5%) was higher than that of single therapy with Jiangni Decoction(75%)or omeprazole and motilium(80%). Motilin[(182.6±43.9)pg/mL] and gastrin[(99.2±31.7 )pg/mL]in reflux esophagitis cases were lower than those in normal control group [(326.6±58.4) pg/mL and (163.1±28.7)pg/mL respectively]. Serum levels of motilin and gastrin increased significantly in three groups after treatment, with the highest level in the combination therapy group. [Conclusion]Omeprazole and motilium and Jiangni Decoction are effective drugs for reflux esophagitis. Combination therapy can not only improve the effect but also promote gastrointestinal motility.更多还原