【摘要】 目的　研究中药复方 (CHP )对 PDAPP转基因小鼠认知功能和记忆能力的影响。方法　应用 Morris水迷宫实验测试 CHP 对 PDAPP转基因小鼠和 C5 7非转基因小鼠的认知和记忆能力的影响。结果　CHP 治疗组 PDAPP转基因小鼠在隐蔽平台实验和可见平台实验中的平均潜伏期明显高于对照组和脑复康组 ,探索实验中在 TQ(targetquadrant)中时间的平均百分比和经过平台位置的次数明显高于其他组。结论　 CHP 对PDAPP转基因小鼠的认知和记忆能力具有明显改善作用.更多还原

【Abstract】 Objective To study the efficacy of Chinese Herbs (CHP Ⅱ) on improving the cognitive function and the ability of memory. Methods We applied the Morris water maze tests to study the efficacy of CHP Ⅱ on improving the cognitive function and the ability of memory. Results From the invisible and visible platform tests, we found that the cognitive function and the ability of PDAPP transgenic mice or C57 non-transgenic mice which were treated with CHP Ⅱ were significantly improved. From the probe test, we found that the mice (both PDAPP mice and C57 non-transgenic mice) treated with CHP Ⅱ takes more time in the TQ (target quadrant), and passed with more times through the position of platform as compared with controls or Piracetam group, respectively. Conclusions CHP Ⅱ has the efficacy on improving thecognitivefunctionandmemory ability of PDAPP mice and non-transgenic mice.更多还原