【摘要】 目的 :研究发热大鼠下丘脑和其他脑组织 15 PGDH活性的时相变化及桂枝汤的影响。方法 :利用Radio TLC法测定发热大鼠及桂枝汤治疗组脑组织不同时间的 15 PGDH活性。结果 :皮下注射酵母后 ,伴随体温的升高 ,大鼠下丘脑PGDH活性先降低后逐渐恢复 ,桂枝汤可阻止该酶早期的活性降低并升高至正常值以上 ;其他脑组织PGDH活性也有类似变化 ,但桂枝汤可抑制后期的PGDH活性向正常恢复。结论 :下丘脑PGDH活性降低 ,参与了酵母性发热的早期机制 ,升高该部位PGDH活性可能是桂枝汤解热机理之一。更多还原

【Abstract】 Objective:To investigate the effect of Guizhi Tang on the time course of cerebral 15 hydroxy prostaglandin dehydrogenase(15-PGDH)in pyretic rats. Methods: The activity of 15-PGDH in hypothalamus and the other cerebral tissues at different time in rats were measured using radio-TLC assay. Results: Paralleled to a fever response induced by a s.c.injection of yeast, the activity of 15-PGDH decreased first,then followed by a gradual return to baselime. Treatment with Guizhi Tang inhibited the decrease of PGDH activity and enhanced it to above normal level;similar changes appeared to the other cerebral tissues while the recover in the later phase was inhibited by Guizhi Tang. Conclusion: Present data suggest that the decrease of the PGDH activity in hypothalamus may contribute to the early stage of fever-induction by yeast in rats and the increase of the enzyme may be one of the antipyretic mechanisms of Guizhi Tang.更多还原