【摘要】 目的 :评价罗非昔布对晚期癌痛病人的镇痛作用。方法 :10 8例经病理学确诊的晚期癌症疼痛病人 ,给予口服罗非昔布片治疗 ,每次 2 5～ 5 0mg ,每天 1次 ,观察病人疼痛缓解情况。 结果 :罗非昔布片每天口服 1次 ,可以有效地控制晚期癌症病人的轻、中度疼痛 ,临床镇痛总有效率为 84 .2 6 %。无明显头晕 ,恶心 ,呕吐 ,胃部不适 ,便秘等不良反应。结论 :罗非昔布片对晚期癌症疼痛有明显的镇痛作用 ,药效持续时间长 ,不良反应小 ,使用方便。更多还原

【Abstract】 Objective:To study the analgesic effect of rofecoxib on patients with advanced carcinoma.Methods:In a randomized clinical trial,108 pathologically diagnosed cancer patients were treated with rofecoxib(dose 25～50mg/d) and the pain relief was observed among all the patients.Results:Rofecoxib was effective in control of cancer related pain in an oral dose of 25～50mg/day with a total effective rate of 84.26%.The main adverse reactions such as drowsiness,dizziness,nausea,vomiting,discomfort in stomach and constipation were slight.Conclusion:Rofecoxib is effective for relieving cancer related pain with sustained duration and slight in adverse reaction and convenient for administration.更多还原