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环孢素A滴眼液的研制

Research and preparation of cyclosporine A eyedrops

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【作者】 左六一解新赵语王晓江

【Author】 ZOU liuyi,et al (Department of Pharmacy,College of Clinical Medicine,Chongqing Medical University)

【机构】 重庆医科大学临床学院药剂科重庆医科大学附属口腔医院药剂科重庆医科大学临床学院药剂科 重庆400016重庆400001重庆400016重庆400016

【摘要】 目的 :建立了环孢素A滴眼液的制备方法。方法 :采用蓖麻油制备环孢素A滴眼液 ,用HLPC测定制剂中环孢素A的含量 ,并对制剂的稳定性进行了考察。结果 :本研究研制的环孢素A滴眼液制备工艺简单 ,质量稳定 ,含量测定快速、准确。结论 :该制剂工艺可用于常规制备环孢素A滴眼液

【Abstract】 Objective:To establish the prescription and preparing procedure for the cyclosporine A eyedrops.Methods:The cyclosporine A eyedrops was prepared from castor oil.The cyclosporine A content of the preparation was determined by HPLC,and stability of the preparation was examined,too.Results:The results showed the procedure of preparation was simple,and the quantitative determination was quick,and accurate while the quality was reliable.Conclusion:The procedure described here can be uesed to prepare the cyclosporine A eyedrops.

【关键词】 环孢素A滴眼液含量测定稳定性
【Key words】 Cyclosporine AEyedropsQuantitative determinationStability
  • 【文献出处】 重庆医科大学学报 ,Journal of Chongqing Medical University , 编辑部邮箱 ,2004年05期
  • 【分类号】R943
  • 【被引频次】5
  • 【下载频次】211
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