【摘要】 目的 :　 分析传统抗精神病药物致高泌乳素血症的精神分裂症 (schizophreniaSP)康复者体内泌乳素 (ProlactinPRL)水平对血清睾酮 (TestosteroneT)、雌二醇 (EstradioEI)、促黄体生成素 (LuteinizinghormoneLH)、促卵泡激素 (FolliclestimulatinghormoneFSH)含量的影响。 方法 :用SEROZYME -I型磁分离酶联免疫测定仪对 77例伴高泌乳素血症的精神分裂症康复者和 40例对照组的血清睾酮、雌二醇、促黄体生成素和促卵泡激素进行测定。 结果 :组 1的受试者血清睾酮、血清雌二醇、促黄体生成素和促卵泡激素的均值与对照组比较有显著性差异 (P <0 0 5 ) ,组 2的受试者血清睾酮、血清雌二醇、促黄体生成素和促卵泡激素的均值与对照组比较有极显著性差异 (P <0 0 1) ;组 3的受试者血清睾酮、血清雌二醇、促黄体生成素和促卵泡激素的均值与对照组比较有极显著性差异 (P <0 0 1)。 结论 :长期处于高泌乳素血症可以继发引起SP康复者体睾酮、雌二醇、促黄体生成素和促卵泡激素分泌紊乱 ,由此引起的并发症防碍精神分裂症患者的有效治愈率 ,甚至会直接增高女性康复者复发的概率。更多还原

【Abstract】 Objective:In order to explore the effect of high prolactin (PRL) level to serum testosterone (T), estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the healing schizophrenic patients. Methods: 77 healing schizophrenic patients with high PRL (study groups: group A, group B and group C) and 40 healing schizophrenic patients with normal PRL (control group) were determined serum T, E2, LH and FSH by magnetism immunity method. Results: The average of T, E2, LH and FSH in group A were distinct difference than the control group ( P <0.05), the average of T, E2, LH and FSH in group B were distinct difference than the control group ( P <0.01), the average of T, E2, LH and FSH in group C were distinct difference than the control group ( P <0.01). Conclusions: High PRL is a mostly causation influencing on serum T, E2, LH and FSH in the healing schizophrenic patients, more than will increase recrudescence in some female healing.更多还原