【摘要】 目的 :探讨西酞普兰治疗强迫症的疗效和安全性。 方法:41例强迫症患者随机分为西酞普兰组 2 1例 ,氯丙咪嗪组 2 0例 ,共治疗 8周 ,采用Yale -Brown强迫量表 (Y -BOCS)、Hamilton抑郁量表 (HAMD)和不良反应量表 (TESS)评定疗效和副反应。 结果 :西酞普兰组与氯丙咪嗪组治疗前后Y -BOCS与HAMD分值比较差异均有显著性 ,而两组减分治疗前后相比差异无显著性。西酞普兰组副作用明显比氯丙咪嗪组小。 结论 :西酞兰治疗强迫症疗效好 ,副反应少 ,依从性好 ,是治疗强迫症的理想药物。更多还原

【Abstract】 Objective: To explore the effect and security of citalopram. Methods: 41 patients with obsessive-compulsive disorder (OCD) were divided into two groups: 21 cases were treated with citalopram and 20 cases were treated with clomipramine (control group) for 8 weeks. The curative effect and side effect were assessed with Y-BOCS, HAMD and TESS. Results: The difference was significant between before and after treatment in Y-BOCS or HAMD score (P<0.01). But the difference of the efficacy between two groups was no significant (P>0.05). The side effects of citalopram group were less then clomipramine group. Conclusions: In the treatment of OCD, citalopram had higher curative effect, fewer side effects and better medication compliance.更多还原