【摘要】 目的:探讨海洛因对依赖者外周静脉血中去甲肾上腺素和肾上腺素的影响。方法:将30例符合DSM-Ⅳ药物依赖诊断标准自愿戒毒者治疗前、后与正常人群外周静脉血中单胺神经递质进行对照研究。抽取病人治疗前、后与正常对照组的外周静脉血,用高效液相色谱仪检测去甲肾上腺素(NE)、肾上腺素(E)。结果:海洛因依赖者治疗前、后比正常对照组外周静脉血中NE含量低,有统计学差异;依赖者治疗前比治疗后、对照组外周静脉血中的E含量高,且有统计学差异。静脉注射和烫吸者治疗前、后NE、E含量,无统计学差异。结论:海洛因对依赖者外周静脉血中去甲肾上腺素和肾上腺素有影响,外源性阿片类药物对神经递质系统有显著的影响,并与用毒和戒断的临床症状相联系。更多还原

【Abstract】 Objective: Investigate the function of heroin dependant’s neuromodulator in peripheral blood. Methods: Compared thirty cases heroin dependant of voluntary detoxification, which associate with 4th revised edition of Diagnostic and Statistic Mental Disorder (DSM - Ⅳ), at the pre and post - drug treatment with control subject for neuromodulator. Pre and post- drug treatment and control subject was drawled blood. Norepi-nephrine (NE) and epinephrine (E) were checked by high efficacy liquid chromatograph. Results: Heroin dependant’ NE at pre and post - drug treatment patient was lower than normal control subject. E at pre - drug treatment patients was higher than post-drug treatment and normal control subject. Conclusion: That heroin dependant’ neuromodulator system in peripheral have been influenced.更多还原