【摘要】 目的观察2型糖尿病患者活化血小板CD62P(P-选择素)、CD63(溶酶体蛋白GP53)的变化及其临床意义。方法应用流式细胞术(FCM)检测糖尿病患者血浆中CD62P和CD63。结果FCM测得血小板CD62P、CD63表达阳性率,2型糖尿病组分别为(4.515±4.532)%,(9.220±4.041)%,明显高于正常对照组〔分别为(1.542±0.614)%,(3.446±0.747)%〕,P均<0.01。结论2型糖尿病患者血浆中CD62P、CD63升高,且随着病程的延长逐渐升高,表明血小板的活化功能明显,并有助于2型糖尿病及其并发症的诊断、治疗及疗效观察。更多还原

【Abstract】 Objective To investigate changes of CD62P and CD63 in patients with type 2 diabetes mellitus and their clinical significance. Methods CD62P and CD63 were analyzed by flow cytometry (FCM). Results The CD62P and CD63 expressions [(4.515±4.532)%; (9.220±4.041)%] on platelets in patients with type 2 Diabetes mellitus were higher than those in normal subjects [(1.542±0.614)%, P<0.01; (3.446±0.747)%, P<0.01]. Conclusions The CD62P and CD63 levels on platelets surface were increased in type 2 Diabetes mellitus. The levels of CD62P and CD63 contributed to diagnosis and treatment of type 2 diabetes mellitus, as well as its therapeutic effect monitoring.更多还原