【摘要】 目的　观察密钙息对原发性骨质疏松症的疗效。方法　将 68例原发性骨质疏松患者随机分为二组 ,观察组给予密钙息及钙剂治疗 ,对照组仅给予同种钙剂口服。治疗 6个月。观察二组治疗前后骨密度变化 ,用药过程中骨痛症状缓解情况 ,血中钙 (Ca2 + )、磷(P5+ )、碱性磷酸酶 (ALP)的变化和药物副反应。结果　①治疗 6个月后 ,二组腰椎、股骨颈骨密度均有提高 ,观察组治疗前后腰椎部位骨密度差异有统计学意义 (P <0 .0 0 5) ;治疗后二组比较差异亦有统计学意义 (P <0 .0 1 ) ;而股骨颈部位骨密度二组治疗前后比较均无统计学意义 ,组间比较亦无统计学意义。②二组用药治疗前后血Ca2 + 、P5+ 、ALP均无显著变化 ,且在正常范围内。③观察组疼痛症状缓解明显 ,对照组无明显改变。④观察组 1例于用药 3个月后出现肌肉颤动 ,余未见不良反应。结论　密钙息能迅速缓解原发性骨质疏松症患者的骨痛 ,并且能提高骨密度 ,副作用小 ,耐受性好。更多还原

【Abstract】 Objective To observe the effect of miacalcic on primary osteoporosis. Methods 68 patients with primary osteoporosis were divided into 2 groups randomly. 50IU miacalcic and peroral calcium were taken by the observed group,while only the same kind of peroral calcium did by the control.The time of observation was 6 months.And the following indexes were observed before and after treatment,as bone mineral density (BMD),the alleviation of bone pain,levels of serum calcium (Ca 2+),serum phosphorus (P 5+),serum alkaline (ALP),and medical side effects. Results ①After 6 months’ treatment,the bone mineral density of lumbar vertebra and neck of femur were increased in the two groups.The bone mineral density of the lumbar vertebra had significant difference before and after the treatment(P<0.005),so did it between two groups after treatment (P<0.01); but the bone mineral density of femur neck had no significant difference in two groups,so did it before and after treatment in each group.②The levels of serum calcium (Ca 2+),serum phosphorus (P 5+),serum alkaline (ALP),within the normal scope,had no significant changes between two groups before and after treatment.③The alleviation of bone pain was obvious in the observed group,but it did mild in the control.④The side effect was not observed in the observed group except a case with muscle vibration occurred 3 months after treatment. Conclusion miacalcic can relieve the bone pain of primary osteoporosis rapidly,and increase bone density, and the side effect is mild also.更多还原