【摘要】 目的　探讨肺炎衣原体抗体 (CPnAb)及C -反应蛋白 (CRP)与血管功能的关系。方法　采集 1 2 0例研究对象空腹静脉血样 ,用酶联免疫吸附法 (ELISA)测定CpnAb免疫球蛋白G(CpnAb -IgG)和CpnAb免疫球蛋白A(CpnAb -IgA) ,用酶免疫法测定CRP。用彩色多普勒超声血流仪检测血管中央的时间 -流速 ,以评估血流量的基线。结果　 79例 (66 % )的CPnAb -IgG滴度≥ 1∶2 ,其中 2 1例同时检测到IgA抗体。 40 %CPnAb -IgG阳性对象 ,通过免疫比浊法检测到CRP水平升高 ,36 %CPnAb -IgA阳性对象同样可检测到CRP水平升高。在CRP阳性的研究对象中 ,80 %检测到CPnAb -IgG ,1 6 %检测到CPnAb -IgA抗体。研究对象中观察到内皮依赖性或内皮非依赖性血管舒张功能同有 /无抗肺炎衣原体IgG升高的差异无统计学意义。血管舒张功能下降与研究对象中检测到CPnAb -IgA或CRP水平升高有关。 结论　血清中的CRP和CPnAb等炎症标志物水平升高与血管功能异常有潜在关系更多还原

【Abstract】 Objective To approach the correlationship between chlamydia pneumonia antibodies (CPnAb)and C-reaction protein(CRP)and vascular function. Methods Fasting venous blood samples of 120 subjects were collected. CPnAb-immunoglobulin G (CPnAb-IgG)、CPnAb-immunoglobulin A (CPnAb-IgA) and CRP were measured by enzyme linked immunosorbent assay (ELISA) and enzyme immunoassay respectively.The baseline flow was estimated with continuous-wave Doppler by recording the time-velocity at mid-vessel. Results Of 79 subjects(66%),the titre level of CPnAb-IgG was more than 1∶2,in which IgA antibodies were detected in 21 cases as well.Elevated CRP levels were detected in 40% CPnAb-IgG positive subjects,and so did 36% CPnAb-IgA positive subjects.Of CRP positive subjects,80% and 16% had detectable CPnAb-IgG and IgA level respectively.No significant difference in endothelium-independent or dependent vasodilation was observed in subjects with or without elevated CPnAb-IgG levels. Conclusion There are a potential association between elevated CRP and CPnAb level and abnormal vascular function.更多还原