【摘要】 目的:探讨热休克蛋白70(HSP70)表达与EB病毒潜在膜蛋白蛳1(LMP蛳1)的关系。方法:采用原位杂交和免疫组化技术对41例鼻咽癌(NPC)和24例癌旁组织进行检测。结果:NPC组织中HSP70阳性率为82.9 %(34/41),高于癌旁组织中HSP70的阳性率(54.2 %,P<0.05)。NPC组织中LMP蛳1阳性率为90.2 %(37/41)。37例LMP蛳1阳性的NPC中有33例(89.2 %)HSP70表达阳性,高于LMP蛳1阴性的NPC(25.0 %,P<0.01)。结论:HSP70的高表达可能涉及NPC的发生发展过程,LMP蛳1可以诱导NPC及癌旁组织HSP70的过表达。更多还原

【Abstract】 Objective: To investigate the expression heat shock protein 70(HSP70) and EB virus latent membrane protein-1 (LMP-1) in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry and in situ hybridization were used to detect the expression of HSP70 and LMP-1 in 41 cases of NPC and 24 cases paratumor tissue. Results: The positive rate of HSP70 in NPC was 82.9 %(34/41), which was significantly higher than that of paratumor tissues (54.2 %, P <0.05). LMP-1 positive rate was 90.2 %(37/41) in NPC, and in 33(89.2 %) of cases, the expression of HSP70 was positive. The positive rate of HSP70 in LMP-1 positive cases were significantly higher than that of LMP-1 negative cases(25.0 %,P <0.01). Conclusion: The results suggested that the expression of HSP70 may be involved in carcinogenesis and development of NPC. The overexpression of HSP70 can be induced by LMP-1 in NPC and paratumor tissue.更多还原